O-133 Follicular flushing increases the number of cumulus oocyte complexes retrieved. A Randomized Controlled Trial

Abstract Study question Does follicular flushing increase the number of cumulus oocyte complexes (COCs) retrieved compared to single aspiration? Summary answer Follicular increases COCs aspiration. What is known already On basis published meta-analyses, does not seem and probability pregnancy. However, eligible RCTs in these meta-analyses are characterized by significant heterogeneity regarding population studied, needle type lumen diameter, aspiration pressure attempts performed. Moreover, most studies do offer information flow rate system used. A constant has been employed a RCT, which higher was after with design, size, duration This single-center, randomized controlled trial, performed between July December 2022. One hundred five patients undergoing retrieval for intracytoplasmic sperm injection, aged <43 years, BMI 18-35kg/m2 were included study. Random allocation each ovary or study nurse on day retrieval, using computer generated randomization list. Patients could enter only once. Participants/materials, setting, methods All follicles ≥11 mm aspirated same double-lumen needle, (190 mmHg) achieve 0.42 ml/sec. If no COC found initial aspirate, corresponding group until retrieved, up maximum times. The primary outcome measure per randomized. Values expressed as median (interquartile range). Main results role chance Significantly more versus group, all [5 (7) 2 (3), p < 0.001, respectively], high [9 (3) 5 (4), normal (2) respectively] low [1 (1) 1 (1), ovarian response. No 2.9% ovaries 16.2% (p 0.001). rate, defined ratio mm, significantly [88.9% (25) 45.5% (37.5), well [81.8% (15.1) (25.0), [85.7% (28.6) 40% (30.0), [100% (0) 50% (100), differences observed maturation fertilization proportion good quality embryos high, Limitations, reasons caution current randomizing instead patients, eliminates attributed multiple confounders allows accurate evaluation true effect retrieved. it allow detection its Wider implications findings first RCT show that aspiration, independently data presented suggests plays an important increasing efficacy retrieval. Trial registration NCT 05473455